2006 - 2013
PhD Bioinformatics
Department of Bioengineering. University of Illinois at Chicago. Chicago, Illinois (USA)
2003 - 2004
MSc Computational Biology
Universidad Complutense de Madrid. Madrid (Spain)
1999
Teaching Certificate (Postgraduate Certificate in Education)
Instituto de Ciencias de la Educación. Universidad Complutense de Madrid. Madrid (Spain)
1998 - 2000
Microbiology PhD Program and Research Certificate
Department of Microbiology I, Universidad Complusense de Madrid.
1993 - 1998
BSc Biology
Facultad de Ciencias. Universidad de Granada. Granada (Spain)
2022 - to date
2021 - 2022. Senior Research Engineer (Academic Staff Research)
2018 - 2020. Senior Computational Biologist (Staff Scientist)
The Ashley lab. Department of Medicine, Division of Cardiovascular Medicine. Stanford University
2015 - 2018
Researcher (Staff Scientist)
The Krogan lab. Department of Cellular and Molecular Pharmacology (CMP). University of California San Francisco (UCSF)
2016 - 2018
Visiting Scientist
Gladstone Institutes. San Francisco, CA
2013 - 2018
Bioengineering Department Affiliate
Department of Bioengineering. University of Illinois-Chicago. Chicago
2014 - 2015
Research Associate (Software Developer and Bioinformatics Specialist)
dictyBase.org. Center for Genetic Medicine. Northwestern University. Chicago
2013 - 2015
Visiting Research Associate
Shannon Hackett's lab. Bird Division. The Field Museum of Natural History. Chicago
2013 - 2014
Visiting Instructor
Prof Bob Eisenberg’s Lab. Department of Molecular. Biophysics & Physiology. Rush University Medical Center. Chicago.
2006 - 2013
PhD Graduate Student
Jie Liang’s Molecular and Systems Computational lab. Department of Bioengineering. University of Illinois-Chicago. Chicago
2003 - 2005
Research Assistant
Proteomics Unit & Department of Microbiology II. Universidad Complutense de Madrid – Parque Científico de Madrid. Madrid
1998 - 2000
Research Assistant
Department of Microbiology I. Faculty of Medicine. Universidad Complutense de Madrid. Madrid.
Peer-reviewed Journals (n = 35) |
2024 - MoTrPAC Study Group, Lead Analysts & MoTrPAC Study Group
Temporal dynamics of the multi-omic response to endurance exercise training
Nature. Volume 629, pages 174–183 (2024). Featured on the cover. doi: 10.1038/s41586-023-06877-w
2024 - David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Charles F. Burant, R. Scott Rector, John Thyfault, Matthew T. Wheeler, Bret H. Goodpaster, Paul M. Coen, Simon Schenk, Sue C. Bodine, Malene E. Lindholm, the MoTrPAC Study Group
The mitochondrial multi-omic response to exercise training across rat tissues
Cell Metabolism. May 02, 2024. doi: 10.1016/j.cmet.2023.12.021
2024 - Gina M. Many, James A. Sanford, Tyler J. Sagendorf, Zhenxin Hou, Pasquale Nigro, Katie L. Whytock, David Amar, Tiziana Caputo, Nicole R. Gay, David A. Gaul, Michael F. Hirshman, David Jimenez-Morales, Malene E. Lindholm, Michael J. Muehlbauer, Maria Vamvini, Bryan C. Bergman, Facundo M. Fernández, Laurie J. Goodyear, Andrea L. Hevener, Eric A. Ortlund, Lauren M. Sparks, Ashley Xia, Joshua N. Adkins, Sue C. Bodine, The MoTrPAC Study Group
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Nature Metabolism. 2024. Epub 2024 May 1. doi: 10.1038/s42255-023-00959-9
2024 - Adriana Steinbach, Varun Bhadkamkar, David Jimenez-Morales, Erica Stevenson, Gwendolyn M. Jang, Nevan J. Krogan, Danielle L. Swaney, and Shaeri Mukherjee
Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila
Molecular Biology of the Cell. 2024 Mar 1;35(3):ar27. doi: 10.1091/mbc.E23-06-0260
2023 - Zeynep Cakir, Samuel J Lord, Yuan Zhou, Gwendolyn M Jang, Benjamin J Polacco, Manon Eckhardt, David Jimenez-Morales, Billy W Newton, Adam L Orr, Jeffrey R Johnson, Alexandre da Cruz, R Dyche Mullins, Nevan J Krogan, Robert W Mahley, Danielle L Swaney
Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP
Molecular & Cellular Proteomics. 2023 May;22(5):100541. Epub 2023 Apr 4. doi: 10.1016/j.mcpro.2023.100541.
2023 - Kristoffer E. Leon, Mir M. Khalid, Ryan A. Flynn, Krystal A. Fontaine, Thong T. Nguyen, G. Renuka Kumar, Camille R. Simoneau, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia Kaye, Priya S. Shah, Steven Finkbeiner, Nevan J. Krogan, Carolyn Bertozzi, Jan E. Carette, Melanie Ott
Nuclear accumulation of host transcripts during Zika Virus Infection
PLoS Pathog. 2023 Jan 5;19(1):e1011070. doi: 10.1371/journal.ppat.1011070.
2022 - SH Lee, X Liu, D Jimenez-Morales, PF Rinaudo
Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production
Elife. 2022 Sep 15;11:e79153. doi: 10.7554/eLife.79153.
2022 - VN Parikh, AG Ioannidis, D Jimenez-Morales ,... , EA Ashley
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy
Nature Communications. 2022 13 (1), 1-10. doi: 10.1038/s41467-022-32397-8.
2022 - Gabriel Mitchell, Melanie R Silvis, Kelsey C Talkington, Jonathan M Budzik, Claire E Dodd, Justin M Paluba, Erika A Oki, Kristine L Trotta, Daniel J Licht, David Jimenez-Morales, Seemay Chou, Paul B Savage, Carol A Gross, Michael A Marletta, Jeffery S Cox
Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms
mBio. 2022 Jan 25;e0272621. doi: 10.1128/mbio.02726-21.
2021 - Malene E Lindholm, David Jimenez-Morales, Han Zhu, Kinya Seo, David Amar, Chunli Zhao, Archana Raja, Roshni Madhvani, Sarah Abramowitz, Cedric Espenel, Shirley Sutton, Colleen Caleshu, Gerald J Berry, Kara S Motonaga, Kyla Dunn, Julia Platt, Euan A Ashley, Matthew T Wheeler
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms
Circ Genom Precis Med. 2021 Nov 22. doi: 10.1161/CIRCGEN.121.003419
2021 - Danielle L. Swaney, Dana J. Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael McGregor, Kari A. Herrington, Rachel O’Keefe, Nan Jin, Nathan K. VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F. Kreisberg, Minkyu Kim, Daniel E. Johnson, Natalia Jura, Jennifer R. Grandis, J. Silvio Gutkind, Trey Ideker, Nevan J. Krogan
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity
Science. Oct 1, 2021. doi: 10.1126/science.abf2911
2021 - Laura Martin-Sancho, Shashank Tripathi, Ariel Rodriguez-Frandsen, Lars Pache, Maite Sanchez-Aparicio, Michael J. McGregor, Kelsey M. Haas, Danielle L. Swaney, Thong T. Nguyen, Joao I. Mamede, Christopher Churas, Dexter Pratt, Sara B. Rosenthal, Laura Riva, Courtney Nguyen, Nish Beltran-Raygoza, Stephen Soonthornvacharin, Guojun Wang, David Jimenez-Morales, Paul D. De Jesus, Hong M. Moulton, David A. Stein, Max W. Chang, Chris Benner, Trey Ideker, Randy A. Albrecht, Judd F. Hultquist, Nevan J. Krogan, Adolfo García-Sastre & Sumit K. Chanda
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy
Nature Microbiology. Sept 23, 2021. doi: 10.1038/s41564-021-00964-2
2021 - Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
Cell Reports. Vol 36, Issue 12, 109742, Sept 21, 2021. doi: 10.1016/j.celrep.2021.109742
2021 - COVID-19 Host Genetics Initiative
Mapping the human genetic architecture of COVID-19
Nature. 2021 Jul 8. doi: 10.1038/s41586-021-03767-x
2021 - Nikoleta G Tsvetanova, Michelle Trester-Zedlitz, Billy W Newton, Grace E Peng, Jeffrey R Johnson, David Jimenez-Morales, Andrew P Kurland, Nevan J Krogan, Mark von Zastrow
Endosomal cAMP production broadly impacts the cellular phosphoproteome
J Biol Chem. 2021 Jun 21;100907. doi: 10.1016/j.jbc.2021.100907
2021 - Aaron J. Wilk, Madeline J. Lee, Bei Wei, Benjamin Parks, Ruoxi Pi, Giovanny J. Martínez-Colón, Thanmayi Ranganath, Nancy Q. Zhao, Shalina Taylor, Winston Becker, Stanford COVID-19 Biobank, David Jimenez-Morales, Andra L. Blomkalns, Ruth O’Hara, Euan A. Ashley, Kari C. Nadeau, Samuel Yang, Susan Holmes, Marlene Rabinovitch, Angela J. Rogers, William J. Greenleaf, Catherine A. Blish
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
J Exp Med. (2021) 218 (8): e20210582. doi: 10.1084/jem.20210582
2020 - The Molecular Transducers of Physical Activity Consortium
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise
Cell. Volume 181, Issue 7, P1464-1474, June 25, 2020. doi: 10.1016/j.cell.2020.06.004
2020 - Jonathan M Budzik, Danielle L Swaney, David Jimenez-Morales, Jeffrey R Johnson, Nicholas E Garelis, Teresa Repasy, Allison W Roberts, Lauren M Popov, Trevor J Parry, Dexter Pratt, Trey Ideker, Nevan J Krogan, Jeffery S Cox
Dynamic post-translational modification profiling of M. tuberculosis-infected primary macrophages
eLife. 2020;9:e51461. doi: 10.7554/eLife.51461 . Datasets assembled into an on-line application: TB OMICS EXPLORER
2019 - Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC.
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen
Cell Host Microbe.. 2019 Sep 10. pii: S1931-3128(19)30426-3. doi: 10.1016/j.chom.2019.08.017
2019 - Adam L. Orra, Chaeyoung Kima, David Jimenez-Morales, Billy W. Newton, Jeffrey R. Johnson, Nevan J. Krogan, Danielle L. Swaney, and Robert W. Mahley
Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function
Journal of Alzheimer's Disease. 2019;68(3):991-1011. doi: 10.3233/JAD-181184
2018 - L. Bramasole, A. Sinha, S. Gurevich, M. Radzinski, Y. Klein, N. Panat, E. Gefen, T. Rinaldi, D. Jimenez-Morales, J. Johnson, N.J. Krogan, N. Reis, D. Reichmann, M.H. Glickman, E. Pick
Proteasome Lid Bridges Mitochondrial Stress with Cdc53/Cullin1 NEDDylation Status
Redox Biol. 2018 Nov 17; 20:533-543
2018 - Krystal A Fontaine, Kristoffer E Leon, Mir Mubashir Khalid, David Jimenez-Morales, Julia Kaye, Priya Shah, Steven Finkbeiner, Nevan Krogan, Melanie Ott
The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein
MBio. 2018 Nov 06; 9(6). Pre-printed at bioRxiv.
2018 - Nan Zhao, Vittorio Sebastiano, Natasha Moshkina, Nacho Mena, Judd Hultquist, David Jimenez-Morales, Yixuan Ma, Alexander Rialdi, Randy Albrecht, Romain Fenouil, Maria Teresa Sanchez-Aparicio, Juan Ayllon, Sweta Ravisankar, Bahareh Haddad, Jessica Sook Yuin Ho, Diana Low, Jian Jin, Yurchenko Vyacheslav, Rabinder Prinjha, Alexander Tarakhovsky, Massimo Squatrito, Dalila Pinto, Allette Kimaada, Minji Byun, Melissa Smith, Robert Sebra, Ernesto Guccione, Terrence Tumpey, Nevan Krogan, Harm van Bakel, Benjamin Greenbaum, Adolfo Garcia-Sastre, and Ivan Marazzi
Influenza virus infection causes global RNAPII termination defects
Nature Structural & Molecular Biology. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3.
2018 - Esther Paulo, Dongmei Wu, Yangmeng Wang, Yun Zhang, Yixuan Wu, Danielle L. Swaney, Margaret Soucheray, David Jimenez-Morales, Ajay Chawla, Nevan J. Krogan & Biao Wang
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Sci Rep. 2018 Jul 20; 8(1):11001
2018 - Kristin L. Patrick, Jason A. Wojcechowskyj, Tao Jing, Morgan Riba, Sara Talmage, Pengbiao Xu, Samantha L. Bell, Ana L. Cabello, Jiewei Xu, Michael Shales, David Jimenez-Morales, Thomas A. Ficht, Paul de Figueiredo, James E. Samuel1, Pingwei Li, Nevan J. Krogan, Robert O. Watson
Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection
2018 - Ruchi Masand, Esther Paulo, Dongmei Wu , Yangmeng Wang, Danielle L. Swaney, David Jimenez-Morales, Nevan J. Krogan, and Biao Wang
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Cell Metab. 2018 Mar 06; 27(3):616-629.e4
2017 - Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang Zhen Z, Laffleur B, Michael R, Haas K, Pefanis E, Albrecht A. R, Jen J, Basu U, Garcia-Sastre A, van Bakel H, Krogan N, Marazzi I
The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.
Cell 2017 May 4;169(4):679-692.e14.
2015 - Basu S, Fey P, Jimenez-Morales D, Dodson RJ, Chisholm RL
dictyBase 2015: Expanding data and annotations in a new software environment.
Genesis 2015 Jun 19.
2014 - Jimenez-Morales D, Adamian L, Shi D, and Liang J.
Lysine Carboxylation: Unveiling a spontaneous posttranslational modification.
Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):48-57
2012 - Jimenez-Morales D, Liang J, and Eisenberg B.
Ionizable Side Chains at Catalytic Active Sites of Enzymes.
Eur Biophys J. Vol 41, Issue 5 (2012), P 449-460.
2012 - Naveed H, Jimenez-Morales D, Tian J, Pasupuleti V, Kenney L, Liang L (2012).
Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding.
J Mol Biol. 2012 May 25;419(1-2):89-101.
2011 - Liang J, Naveed H, Jimenez-Morales D, Adamian L, Lin M.
Computational studies of membrane proteins: Models and predictions for biological understanding.
Biochim Biophys Acta. 2011 Oct 12.
2011 - Jimenez-Morales D and Liang J.
Pattern of Amino Acid Substitutions in Transmembrane Domains of β-Barrel Membrane Proteins for Detecting Remote Homologs in Bacteria and Mitochondria.
PLoS ONE. 2011;6(11):e26400. Epub 2011 Nov 1.
2008 - Jimenez-Morales D, Adamian L, and Liang J.
Detecting Remote Homologues Using Scoring Matrices Calculated from the Estimation of Amino Acid Substitution Rates of Beta-Barrel Membrane Proteins.
Conf Proc IEEE Eng Med Biol Soc. 2008, 30:1347-1350.
2008 - Jimenez-Morales D.
Substitution Rates of Amino Acid residues in Transmembrane Regions of Beta-Barrel Membrane Proteins.
BioE Student Journal. N1, 2008. Front Cover.
Books (n = 2) |
2001 - Coauthor.
Propiedades adicionales no antibióticas de los macrólidos.
Scientific Communication Management Editors.
2001 - Coauthor.
Guía Setas Autóctonas.
Editorial Doyma. Madrid.
Popular Science Articles (n = 2) |
2000 - Jimenez-Morales D.
Problematic in the use of antiobiotics in animal farms.
Nº41. Ganaderos Magazine. sp
2000 - Jimenez-Morales D.
Bovine spongiform encephalopathy.
Nº37. Ganaderos Magazine.
Abstracts & Communications (n = 20) |
2024 - Jimenez-Morales D, MoTrPAC study group
MoTrPAC Data Hub: Comprehensive Multi-Omic, Multi-Tissue Insights into Exercise Molecular Responses
International Biochemistry of Exercise Conference (IBEC). Limerick, Ireland (July 2024). Oral Communication.
2024 - Jimenez-Morales D, Malene E Lindholm, Jimmy Zhen, Mihir Samdarshi, Jay Yu, Christopher Teng, Archana Raja, David Amar, MoTrPAC study group, Euan A Ashley, Matthew T Wheeler.
MoTrPAC Data Hub: Multi-omic, Multi-tissue Collection of Exercise Molecular Responses
Cell Symposia: Exercise Metabolism. Lisboa, Portugal (May 2024)
2024 - Jimenez-Morales D, MoTrPAC study group
Unveiling the Multi-omic Landscape of Endurance Exercise: Biological Insights and Data Integration from the MoTrPAC Study.
The NIH CFDE All-Hands Meeting. Bethesda, USA (March 2024). Oral Communication, talk awarded.
2021 - Jimenez-Morales D, Raja AN, Hershman SG, Amar D, Petyuk VA, Monroe ME, Nestor MD, Sanford JA, Beltran PMJ, Keshishian H, Mani DR, Ashley EA, Carr SA, Adkins JN, Wheeler MT
CloudProteo: a comprehensive cloud-based proteomics data analysis pipeline
69th Annual Conference American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics. 2021 Philadelphia, Pennsylvania
2021 - Beltran PMJ, Keshishian H, Mundorff C, Pearce C, Mani DR, Karsten Krug, Clauser K, Gay NR, Amar D, Jimenez-Morales D, Sanford JA, Avila Pacheco J, Dennis Courtney, Ilkayeva O, Bodine SC, Gerszten R, Newgard C, Clary Clish C, Carr SA
An Integrative Molecular View of Mammalian Adaptation to Exercise Training
69th Annual Conference American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics. 2021 Philadelphia, Pennsylvania
2019 - David Jimenez-Morales
artMS: Analytical R Tools for Mass Spectrometry (Link to slides)
Oral communication. 2019 SUMS-RAS (Stanford University Mass Spectrometry - Research Application Symposium). Stanford, CA
2019 - David Jimenez-Morales, John Von Dollen, Alexandre Rosa Campos, Nevan J Krogan, Danielle Swaney
artMS: Analytical R Tools for Mass Spectrometry
67th Annual Conference American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topicds. 2019 Atlanta, Georgia
2017 - David Jimenez-Morales, Judd Hultquist, John Von Dollen, Jeff Johnson, Hannes Braberg, and Nevan J Krogan
Influenza virus networks of pathogenesis inferred from the integration of multiple large-scale datasets.
Oral communication. Annual Programmatic Meeting. NIAID-NIH, Systems Biology for Infectious Diseases (SBID) Research. May 7-10, 2017 Chicago, IL.
2017 - Kelsey Haas, Michael McGregor, David Jimenez-Morales, Judd Hultquist, and Nevan Krogan
Destroying the “Non-self”: Defining Influenza A Viral Endonuclease Mechanisms for Host Shutoff.
Annual Programmatic Meeting. NIAID-NIH, Systems Biology for Infectious Diseases (SBID) Research. May 7-10, 2017 Chicago, IL.
2017 - Judd F. Hultquist, David Jimenez-Morales, Michael M. McGregor, Kelsey Haas, Jeffrey Johnson, William Newton, Giorgi Metreveli, Matthew Urbanowski, Megan Shaw, Ivan Marazzi, Randy A. Albrecht, Adolfo Garcia-Sastre, and Nevan J. Krogan
Proteomic Profiling of Influenza A Virus Infection Reveals Strain-specific Rewiring of Host Cell Networks.
Annual Programmatic Meeting. NIAID-NIH, Systems Biology for Infectious Diseases (SBID) Research. May 7-10, 2017 Chicago, IL.
2017 - Celina Cahalane, David Jimenez-Morales, John VonDollen, Hannah Baumann, Matthew Urbanowksi, Megan Shaw, Giorgi Metreveli, Nevan Krogan, Adolfo Garcia-Sastre, Oswald Quehenberger, Edward Dennis, and Leah Shriver
Metabolic Profiling of Influenza Infection.
Annual Programmatic Meeting. NIAID-NIH, Systems Biology for Infectious Diseases (SBID) Research. May 7-10, 2017 Chicago, IL.
2016 - David Jimenez-Morales, Judd Hultquist
FluOMICs data integration for the identification of networks involved in host responses to influenza virus infection
Oral communication. The 2016 Systems Biology Programmatic Meeting. NIAID-NIH, Systems Biology for Infectious Diseases (SBID) Research. Apr 10-13, 2016 New York, NY.
2016 - Jimenez-Morales D, Von Dollen J, Braberg H, Verschueren E, and Krogan NJ.
Predictive models for the identification of networks involved in host responses to influenza virus infection.
2nd Annual Host- Pathogen Interactions: Circuits to Systems Symposium. Jan 4, 2016. San Diego, CA.
2015 - Jimenez-Morales D
The new face of dictyBase
Oral communication. dicty2015: Annual International Dictyostelium Conference. August 9th-13th. London, United Kingdom
2011 - Jimenez-Morales D, Liang J, and Eisenberg B.
Active Sites of Enzymes are Crowded with Charge.
Biophysical Journal. 100(3): p. 218a. Abstract 1191-Pos and Poster Board B101.
2011 - Jimenez-Morales D, Liang J, and Eisenberg B.
Active Sites of Enzymes are Crowded with Charge.
6th Annual Midwest Conference on Protein Folding, Assembly, and Molecular Motions. University of Notre Dame.
2010 - Jimenez-Morales D, Li R, Wang Z, Li Y, Liu L, Liang J.
Evolutionary Speed of Enzymes Functional Surfaces and their Relationship with Metabolic Fluxes in Networks of Central Carbon Metabolism of Bacteria.
Biophysical Journal 98(3) pp. 741a
2008 - Jimenez-Morales D, Adamian L, Liang J.
Substitution Rates Of Amino Acid Residues In Transmembrane - Extracellular And Periplasmic- Regions Of Beta-Barrel Membrane Proteins.
Biophysical Journal 94(2) pp. 1959
2002 - Jimenez-Morales D.
Tools for the Apored Virtual.
V-Aporeunión. Tordesillas (Valladolid). Oral presentation: I introduced the improvements in the new Apoweb.
1999 - Jimenez-Morales D, Heredia S, Calvo A, Gomez-Luz ML, Prieto J.
Sensibilidad a antimicrobianos de Enterococcus faecalis de procedencia animal.
Spanish Chemotherapy Society Congress. May 1999
PhD Thesis |
2013 - Jimenez-Morales D
Effects of Physicochemical and Functional Constraints on the Sequence and Structure of Proteins
Bioengineering Department, University of Illinois at Chicago 06/2013
Workshop Instructor
Association of Biomolecular Resource Facilities (ABRF)
March 2021 - Using R in Proteomics Core: from QC to Data Analysis. Slides
Courses as Instructor
Department of Bioengineering. University of Illinois at Chicago.
Fall 2010 - BIOE480: Introduction to Bioinformatics.
Fall 2012 - BIOE481: Bioinformatics Laboratory.
Courses as Teaching Assistant
Department of Bioengineering. University of Illinois at Chicago.
Spring 2013 - BIOE250, Clinical Problems in Bioengineering.
Fall 2012 - BIOE481: Bioinformatics Laboratory.
Fall 2010, 2012 - BIOE480, Introduction to Bioinformatics.
Spring 2007 - BIOE455, Intro to Cell and Tissue Engineering.
Fall 2006 - BIOE240, Modeling Physiological Data & Systems
I have led/developed the following tools:
OmicsPipelines: Conceived, directed, and supervised the development of OmicsPipelines, a user-friendly tool that empowers researchers to efficiently utilize cloud computing for genomic, transcriptomic, and proteomic analyses. This tool streamlines complex bioinformatics workflows, significantly enhancing data processing efficiency and accuracy for research teams, without requiring in-depth knowledge of cloud environment complexities.
R package: artMS: Analytical R Tools for Mass Spectrometry. Check the Github repo and the Bioconductor page.
R package: MotrpacBicQC: Primary and Secondary QC/QA analysis of datasets generated by the Metabolomic and Proteomic Chemical Analysis Sites (CAS) of the Molecular Transducer of Physical Activity Consortium (MoTrPAC)
CAS to BIC Data Transfer QC Monitor: QC monitor tool that reports in real time datasets submitted and processed by the MoTrPAC Bioinformatics Center
bioNeNa (the FluOMICS bioNetwork Navigator): a systems biology tool to explore large-scale datasets (Unfortunately, the tool is currently unfunded and its functionality is significantly limited)
TB OMICS EXPLORER: Multi-OMICS profiling of primary macrophages during Mycobacterium tuberculosis (TB) infection (part of this publication)
MIDTOD: Metabolite Identification Through Orthogonal Datasets (under development).
PreLysCar (Predictor of Lysine Carboxylation), also available as a tool in the suite of structural biology programs CCP4
bbTM-ST (beta-barrel TransMembrane Search Tool).
Operating Systems: Unix/Linux and Mac OS X. Virtual Computing: Docker, Vagrant.
Cloud Computing: Google Cloud Platform (GCP); AWS; Azure
Pipeline/Workflow: Work Definition Language (WDL); Cromwell
Programming languages: R (also Shiny), Python, Perl, Unix shell scripts, HTML, CSS (Bootstrap), Javascript (AngularJS, Node.js), Ruby on Rails, PHP, Matlab, C/C++, Java.
Bioinformatics Packages. Sequence analysis software (Blast, MEME-MAST, ClustalW, T-Coffee, HMMER, HHsearch,...); Molecular structures visualization software (PyMOL, VMD, Rasmol, Dino, SPDBV); Molecular dynamics (NAMD); Molecular interactions (Mint, Osprey); Genomics: Maker, FastQC, ALLPATHS-LG, Circos, GeneMark, QIIME, Galaxy; etc
Databases: Relational: PostgreSQL & MySQL. SQL language. Generic Model Organism Database Chado schema of relational databases. NoSQL databases: Neo4j. Search engine: elasticsearch
GMOD tools: JBrowse, WebApollo, InterMine.
Others: Source code management (git/github); Design (Photoshop); Statistician (R, SAS, SPSS).
2017 - Krogan Lab. UCSF. San Francisco, CA (USA)
2016 - FluOMICS. UCSF. San Francisco, CA (USA)
2016 - New Dictybase. Dictybase. Northwestern University. Chicago (IL, USA)
2015 - dictyMeeting 2015. Dictybase. Northwestern University. Chicago (IL, USA)
2003 - Proteomic Unit. Facultad de Farmacia. UCM-PCM (Madrid, Spain)
2002, 2005 - Spanish Network of Apoptosis (APORED) Department of Cell and Developmental Biology. Centro de Investigaciones Biológicas (CIB-CSIC)
2002 - 2005 - Spanish Network of Apoptosis (APORED). Department of Cell and Developmental Biology. CIB-CSIC. Administrator of workspace BSCW (Basic Support for Cooperative Work) of the APORED. List co-administrator of APORED email distribution list, and list administrator of Apobecarios email distribution list. Website updates
Google Cloud Research Innovators Program Participant
2024, Google Cloud
U19AI135972: “FluOMICS, The Next Generation”.
2018 – 2022. Co-PI Modeling Core. Co-PI Data Management and Bioinformatics Core (DMBC). NIH/NIAID
Pilot Project (U19AI106754): “Development of a web-based computational tool for integrating and navigating systems biology data and models”.
2017 – 2018. Principal Investigator. NIH/NIAID
Beca Talentia Excellence Grant
2008 - 2010. Regional Ministry for Innovation, Science and Enterprise. Junta de Andalucía. Spain.
Videos
- Learn how soap stops the coronavirus (by Sarartistic). También disponible en español
- A segment about MoTrPAC in the TODAY show