Enrichment of changes in protein abundance or PTMs

Enrichment analysis of the selected proteins

artmsEnrichLog2fc(
  dataset,
  species,
  background,
  heatmaps = FALSE,
  output_name = "enrichment.txt",
  verbose = TRUE
)

Arguments

dataset	(data.frame) with a Gene and Comparison or Label (with the name of the comparisons specified in the contrast file) columns
species	(char) Specie, only supported "human" or "mouse"
background	(vector) Background genes for the enrichment analysis.
heatmaps	(logical) if TRUE generates heatmaps (pdf), FALSE (default) otherwise.
output_name	(char) Name of the annotation files, which will be used as well for the heatmaps (if heatmaps is selected) Default output_name = "enrichment.txt"
verbose	(logical) TRUE (default) shows function messages

Value

(data.frame) Results from the enrichment analysis using Gprofiler and heatmaps (if selected)

Examples

if (FALSE) {
# The data must be annotated (Protein and Gene columns)
data_annotated <- artmsAnnotationUniprot(
                      x = artms_data_ph_msstats_results,
                      columnid = "Protein",
                      species = "human")
# And then the enrichment
enrich_set <- artmsEnrichLog2fc(
                   dataset = data_annotated,
                   species = "human",
                   background = unique(data_annotated$Gene))
}